The Global Health Security Agenda (GHSA) is a multilateral initiative to improve international compliance with the International Health Regulations (IHR), especially related to preparedness to face threats posed by infectious diseases. The GHSA comprises 70 countries, international organizations and non-government organizations that work together to identify and fill gaps in country capacity to prevent, detect and respond to infectious disease threats. The GHSA encourages collaboration between the health, security, environmental and agricultural sectors, and emphasizes that global health security should be a priority for national leaders. The GHSA focuses on common, measurable targets that can be easily understood by everyone who engages with it. 

The GHSA was first founded in 2014 by the World Health Organization (WHO) and the United States with a 5 year mandate, which was renewed for another five years in 2017. In the first phase of GHSA, the focus was on the evaluation of health security capacity, and they found that 70% of countries surveyed were prepared to address a global pandemic (this assessment was prior to the COVID-19 pandemic). In the second phase of the GHSA, which is currently ongoing, the focus is on planning and resource mobilization to close gaps and strengthen capacities.  The GHSA is governed by a Steering Group of 15 rotating GHSA members, whose main tasks are to provide strategic guidance, identify overall GHSA priorities and coordinate among GHSA members.