The World Health Organization (WHO) Biorisk Management: Laboratory biosecurity guidance was designed to help laboratory managers and national regulators strike a balance between traditional laboratory biosafety and broader laboratory biosecurity requirements. The guidelines were released in 2006 as a companion to Laboratory Biosafety Manual 3rd edition as a result of laboratory acquired SARS-CoV-1 infections in 2003-2004 in Singapore, Taipei and Beijing. The guidance builds upon the biorisk management framework outlined in LBM 3rd edition, and focuses more on laboratory biosecurity, in addition to biosafety. It also analyzes gaps in the current biosecurity system and proposes solutions. The target audience for the guidance is regulators, laboratory managers and laboratory personnel. 

The guidance breaks down biorisk management into seven main components: 1. Use risk assessments to determine which biological materials need which level of protection, 2. Establish a clear chain of command, 3. Promote a culture of responsibility, 4. Balance security policy with research progress, 5. Strengthen collaboration between the scientific, technical and security sectors. 6. Provide appropriate training to employees of laboratory facilities. 7. Strengthen emergency response and recovery plans on the assumption that biorisk management systems can only minimize, but never really eliminate, every conceivable threat. Much of this guidance was expanded upon and incorporated into the LBM 4th edition.